Exploring the Intricate Connection Between Vitamin B12 Deficiency and Hearing Loss: A Systematic Literature Review

Rodrigues et al. (2025) completed a meta-analysis of nine studies investigating a relationship between low B12 blood serum levels and hearing loss. Across studies, low levels of vitamin B12 were associated with greater hearing loss at and above 4 kHz. The studies included in this analysis controlled for confounding variables like age and gender. Interestingly, the studies included in this review were heterogeneous in their findings of greater hearing loss in those with low vitamin B12 when compared to those with normal or high levels. The researchers hypothesized that low vitamin B12, coupled with high homocysteine levels and low folate, may contribute to hearing loss in the elderly.

References

Rodrigues J, Anand S, Gunjawate D, Kumar K, Ravi, R. (2025) Exploring the intricate connection between vitamin B12 deficiency and hearing loss: A systematic literature review. Ear Nose Throat J.