Recovery from TBI
A recent study suggests that recovery from TBI (traumatic brain injury) may be different between males and female subjects. Historically, TBI studies have used predominately male subjects, whether they be mice or men. However, investigating the effects of injury, disease, and pharmacological treatments in both male and female subjects has led to significant changes to clinical practice across numerous disciplines. Villapol et al (2017) found that in the seven days following TBI the rate of spread and inflammatory responses were significantly different between male and female mice. By understanding the differences between the sexes, TBI rehabilitation may ultimately be tailored with gender as a critical factor.
Villapol S, Loane DJ, Burns MP. (2017) Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia. 2017;65(9):1423–1438.