Skip to content
American Academy of Audiology
  • PRACTICE RESOURCES
    • Practice Guidelines and Standards
    • Reimbursement
    • Coding
    • Compliance
    • Public Awareness
    • State Medicaid
    • Medicare FAQs
    • COVID-19 Resources
  • EDUCATION & EVENTS
    • Event Calendar
    • Academy Research Conference (ARC)
    • Continuing Education
    • eAudiology Online Learning
    • Research Grants and Scholarships
  • AAA ANNUAL CONFERENCE
    • Attend
    • Exhibit Hall
    • Program and Events
    • Exhibit and Sponsorship Opportunities
    • About
  • NEWS & PUBLICATIONS
    • Audiology Today
    • Newsroom
    • Journal of the American Academy of Audiology
    • Advertising
    • Audiology Solutions Network
    • Online Store
    • Permissions and Reprints
  • CAREERS
    • Career Center
    • Certification
    • Become an Audiologist
    • Doctoral Programs in Audiology
    • Recruiting
    • Resources for New Audiologists
  • ADVOCACY
    • Legislative and Regulatory Activities
      • State Affairs
      • Federal Affairs
    • Legislative Action Center
    • Government Relations News
  • ABOUT THE ACADEMY
    • Contact Us
    • Academy Membership
      • Benefits
      • Ethics
      • Member Directory
      • Membership Renewals
    • Leadership
    • Committees and Task Forces
    • Get Involved
    • Diversity, Equity, and Inclusion
    • Honors and Awards
    • Sponsorships and Corporate Partners
    • Press and Media Information
  • AUDIOLOGY COMMUNITY
  • CONSUMERS
    • What Is an Audiologist
    • Hearing and Balance Symptoms and Conditions
    • Managing Hearing Loss
    • Seniors and Hearing Loss
    • Children and Hearing Loss
FacebookTwitterLinkedinYoutubeInstagram
  • Audiology Community
  • Students
  • Get Involved
  • Donate
  • Renew
American Academy of Audiology
Member Login
  • PRACTICE RESOURCES
    • Practice Guidelines and Standards
    • Reimbursement
    • Coding
    • Compliance
    • Public Awareness
    • State Medicaid
    • Medicare FAQs
    • COVID-19 Resources
  • EDUCATION & EVENTS
    • Event Calendar
    • Academy Research Conference (ARC)
    • Continuing Education
    • eAudiology Online Learning
    • Research Grants and Scholarships
  • AAA ANNUAL CONFERENCE
    • Attend
    • Exhibit Hall
    • Program and Events
    • Exhibit and Sponsorship Opportunities
    • About
  • NEWS & PUBLICATIONS
    • Audiology Today
    • Newsroom
    • Journal of the American Academy of Audiology
    • Advertising
    • Audiology Solutions Network
    • Online Store
    • Permissions and Reprints
  • CAREERS
    • Career Center
    • Certification
    • Become an Audiologist
    • Doctoral Programs in Audiology
    • Recruiting
    • Resources for New Audiologists
  • ADVOCACY
    • Legislative and Regulatory Activities
      • State Affairs
      • Federal Affairs
    • Legislative Action Center
    • Government Relations News
  • ABOUT THE ACADEMY
    • Contact Us
    • Academy Membership
      • Benefits
      • Ethics
      • Member Directory
      • Membership Renewals
    • Leadership
    • Committees and Task Forces
    • Get Involved
    • Diversity, Equity, and Inclusion
    • Honors and Awards
    • Sponsorships and Corporate Partners
    • Press and Media Information
  • AUDIOLOGY COMMUNITY
  • CONSUMERS
    • What Is an Audiologist
    • Hearing and Balance Symptoms and Conditions
    • Managing Hearing Loss
    • Seniors and Hearing Loss
    • Children and Hearing Loss
February 8, 2022

A Combinatorial Approach to Protect Sensory Tissue

Against Cisplatin-Induced Ototoxicity

  • In the News

As we know, a commonly used chemotherapeutic agent, Cisplatin, is very effective in treating malignant tumors. Often, however, patients experience irreversible hearing loss and/or tinnitus. The percentage of patients suffering from Cisplatin ototoxicity is between 11 percent and 97 percent with an average incidence of 62 percent of adult patients, and 60 percent of pediatric patients being affected overall (Chirtes and Albu, 2014).

A decrease in ototoxicity of these lifesaving drugs is a major area of investigation in oncology, otolaryngology, and hearing research. Several potential otoprotective agents have been investigated but none have received full approval by the U.S. Federal Drug Administration. Febles et al (2022) studied the effects of an otoprotective treatment that was comprised of an antioxidant, a p53 inhibitor, and a neurotrophic.

In-vitro and ex vivo findings in rats demonstrated that with the three agents in combination as an otoprotective, Cisplatin-induced hair cell damage, death, and spiral ganglion fiber loss were significantly reduced.

The authors conclude and recommend an immediate local administration of the cocktail may promise clinical prevention of Cisplatin-induced sensorineural hearing loss and tinnitus.

References

Chirtes F, Albu S. (2014) Prevention and restoration of hearing loss associated with use of Cisplatin. Biomed Res Int (925485):1–9.

Febles NK, Bauer MA, Ding B, Zhu X ,Gallant ND, Frisina RD. (2022). A combinatorial approach to protect sensory tissue against cisplatin-induced ototoxicity. Hear Res (415) 108430:1–11.

Share this

Recent Posts

President’s Message: Academy Teamwork

“Huh?” Is More Than an Interrogatory Palindrome!

Volunteer Spotlight: Riley DeBacker, AuD, PhD

Related Posts

In the News

“Huh?” Is More Than an Interrogatory Palindrome!

“Huh?” is used in at least 31 languages around the world! A version of the word can be found in nearly every language on Earth (Dingemanse et al, 2013). This research concluded that all languages studied included a word similar, in both sound and function, to the English “huh?” Regardless of language, the word is…

Read More
In the News

Another Useless Body Part…

If you have a dog or cat, you’ve probably seen their ears moving toward an interesting or startling sound. For professional equestrians, watching the ears of their horse allows them to gauge their shifting attention. Humans still have these same muscles, and even more interesting is their relationship to our brain and how we pay attention. …

Read More
In the News

Memorizing Movements: How Tai Chi Can Improve Balance and Cognition

Tai Chi is not just for increasing balance; it may also help improve cognitive performance. In a recent randomized controlled trial, study participants who practiced a form of Tai Chi twice a week for six months improved their scores on the Montreal Cognitive Assessment (MoCA) when compared to a control group (Fuzhong et al, 2023)….

Read More
wave-mark

Join the Academy

Academy members receive many benefits for professional development, practice management, and community development.

Become a Member
COMM22-Academy_Website_Graphics-Retina-Celebrating_35_Years (W)-min

American Academy of Audiology
11480 Commerce Park Drive
Suite 220
Reston, VA 20191

Tel: 703-790-8466
Fax: 703-790-8631

  • Practice Resources
  • Education and Events
  • AAA Annual Conference
  • News and Publications
  • Careers
  • Advocacy
  • About the Academy
  • Consumers and Patients
  • Audiology Community
  • Students
  • Donate
  • Get Involved
  • Contact Us
  • Privacy Policy
  • Antitrust Policy and Guidelines
  • Terms of Use Policy
  • Accessibility Statement
  • Sitemap

© Copyright 2023 American Academy of Audiology

Website by Yoko Co

Scroll To Top