Washington University School of Medicine and the University of Iowa may have discovered a new way to prevent noise-induced hearing loss.

In this study, researchers tested a drug compound on mice before exposing them to 100 dB SPL for 2 hours. By utilizing a drug that targets a selective blockade of Calcium permeable AMPA receptors, they found that the mice were protected against noise-induced synaptopathy. This study could impact the way we prevent hearing loss through noise exposure.

Reference

Hu N, Rutherford MA, Green SH. (2020) Protection of cochlear synapses from noise-induced excitotoxic trauma by blockade of Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences. February 3.

Share this

Related Posts

Benefits of Physical Activity

Has watching the 2020 Summer Olympics inspired you to increase your physical activity? The July issue of National Institutes of Health (NIH) Health in News mentions the recommendation that adults get 150 minutes of moderate physical activity or 75 minutes of intense activity per week, as well as strength training twice weekly. Unfortunately, most Americans…

Read More

Clinical and Genetic Risk Factors for Radiation—Associated Ototoxicity

Cranial radiation therapy (CRT) is associated with ototoxicity, which manifests as hearing loss and tinnitus. This article sought to identify clinical determinants and genetic risk factors for ototoxicity among adult survivors of pediatric cancer treated with CRT. Analyses were completed on 4,938 patients who survived childhood cancer (diagnosed 1970–1986) and were not treated with cisplatin…

Read More

The Vestibular System Takes Home the Gold

The vestibular system in the average human is an intricate network incorporating multiple inputs so that equilibrium is maintained. The vestibular system of an elite athlete who regularly defies gravity, making complex rotations look routine is exquisite. Watching the Olympic athletes maneuver in the air with precise knowledge of where their body is in relation…

Read More