In September 2022, the U.S. Food and Drug Administration (FDA) approved PEDMARK® (sodium thiosulfate) to reduce the risk of cisplatin-induced hearing loss in children receiving this cancer treatment. Cisplatin is a commonly-used chemotherapeutic agent for treatment of brain, bone, and liver cancers. During treatment, the accumulation of cisplatin in the inner ear may result in sensorineural hearing loss, particularly in children.
The road to this FDA approval began almost 30 years ago in an Oregon Health and Science University (OHSU) laboratory led by Edward Neuwelt, MD, professor and lead researcher in the Department of Neurology at OHSU. Their bench-to-bedside approach to examining the benefits of this drug required intense collaboration among researchers, scientists, clinicians, families, and cancer survivors. The FDA has approved the use of PEDMARK® for patients ranging in age from one month up to 18 years who have localized tumors.
Oregon Health and Science University News. (2023) Driven by OHSU research, FDA approves new drug to prevent hearing loss in children with cancer (accessed February 16, 2023).
If you have a dog or cat, you’ve probably seen their ears moving toward an interesting or startling sound. For professional equestrians, watching the ears of their horse allows them to gauge their shifting attention. Humans still have these same muscles, and even more interesting is their relationship to our brain and how we pay attention. …
Tai Chi is not just for increasing balance; it may also help improve cognitive performance. In a recent randomized controlled trial, study participants who practiced a form of Tai Chi twice a week for six months improved their scores on the Montreal Cognitive Assessment (MoCA) when compared to a control group (Fuzhong et al, 2023)….
The majority of people are familiar with earthquakes, but there is another phenomenon that is not nearly as predictable, and louder—skyquakes. Skyquakes are enigmatic sounds, typically described as a very loud boom or trumpet-sounding noise that has no apparent cause and seems to come from the sky. Their sound is like distant, but very loud, thunder with…